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As a result, immunosuppressive TAMs accumulate in gliomas, where they secrete IL-10, TGF-, arginase-1, and other factors that dampen T cell responses and support tumor growth (71, 72)

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20 Table 71: Exposure (Active-Controlled RCTs, add-on to 1 to 2 OADs) EMPA = empagliflozin

-TOH administration, initiated post-SE, restored the dendritic spine density to near-control levels, suggesting that it promotes the formation of new spine rather than preventing acute loss